Low-Dose vs Standard-Dose Insulin in Pediatric Diabetic Ketoacidosis

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Low-dose vs standard-dose insulin in pediatric diabetic ketoacidosis: a randomized clinical trial.

IMPORTANCE The standard recommended dose (0.1 U/kg per hour) of insulin in diabetic ketoacidosis (DKA) guidelines is not backed by strong clinical evidence. Physiologic dose-effect studies have found that even lower doses could adequately normalize ketonemia and acidosis. Lowering the insulin dose may be advantageous in the initial hours of therapy when a gradual decrease in glucose, electrolyt...

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Is a Priming Dose of Insulin Necessary in a Low-Dose Insulin Protocol for the Treatment of Diabetic Ketoacidosis?

OBJECTIVE The purpose of this study was to assess the efficacy of an insulin priming dose with a continuous insulin infusion versus two continuous infusions without a priming dose. RESEARCH DESIGN AND METHODS This prospective randomized protocol used three insulin therapy methods: 1) load group using a priming dose of 0.07 units of regular insulin per kg body weight followed by a dose of 0.07...

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Low Dose Insulin Regimen for Diabetic Coma

Introduction Low dosage insulin regimens for diabetic "comas" have recently attracted considerable attention (Alberti, Hockaday and Turner, 1973; Page et al, 1974; Kidson et al, 1974; Semple, White and Manderson, 1974). These regimans have all originated from established diabetic centres, however the simplicity of these regimens, especially the intra muscular regimen (Alberti et al, 1973), woul...

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Low dose vs standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysis.

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ژورنال

عنوان ژورنال: JAMA Pediatrics

سال: 2014

ISSN: 2168-6203

DOI: 10.1001/jamapediatrics.2014.1211