Low-Dose vs Standard-Dose Insulin in Pediatric Diabetic Ketoacidosis

Low-dose vs standard-dose insulin in pediatric diabetic ketoacidosis: a randomized clinical trial.

IMPORTANCE The standard recommended dose (0.1 U/kg per hour) of insulin in diabetic ketoacidosis (DKA) guidelines is not backed by strong clinical evidence. Physiologic dose-effect studies have found that even lower doses could adequately normalize ketonemia and acidosis. Lowering the insulin dose may be advantageous in the initial hours of therapy when a gradual decrease in glucose, electrolyt...

Is a Priming Dose of Insulin Necessary in a Low-Dose Insulin Protocol for the Treatment of Diabetic Ketoacidosis?

OBJECTIVE The purpose of this study was to assess the efficacy of an insulin priming dose with a continuous insulin infusion versus two continuous infusions without a priming dose. RESEARCH DESIGN AND METHODS This prospective randomized protocol used three insulin therapy methods: 1) load group using a priming dose of 0.07 units of regular insulin per kg body weight followed by a dose of 0.07...

Low Dose Insulin Regimen for Diabetic Coma

Introduction Low dosage insulin regimens for diabetic "comas" have recently attracted considerable attention (Alberti, Hockaday and Turner, 1973; Page et al, 1974; Kidson et al, 1974; Semple, White and Manderson, 1974). These regimans have all originated from established diabetic centres, however the simplicity of these regimens, especially the intra muscular regimen (Alberti et al, 1973), woul...

Low dose vs standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysis.

BACKGROUND It remains unknown as to whether the antipsychotic dose needed for the acute-phase treatment of schizophrenia is also necessary for relapse prevention. AIM To compare the efficacy between standard dose [(World Health Organization daily defined dose (DDD)] vs low dose (≥50% to <1 DDD) or very low dose (<50% DDD) for relapse prevention in schizophrenia. DATA SOURCE Double-blind, ra...

Diabetic ketoacidosis and pediatric stroke.